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Schmidt Reaction:
In presence of concentrated H2SO4,carboxylic acid react with hydrazoic acid, to give amine.
when aldehyde reacts with hydrazolic acid then a mixture of cyanide and formyl derivatives are formed.
when ketone reacts with hydrazoic acid then amides are formed.
Mechanism:
a) Reaction with carboxylic acid.
b)Reaction with aldehyde:
c)Reaction with ketone:
Applications:
1)Preparation of primary amines-
This reaction is useful in the direct conversion of carboxylic acid into primary amine but hydrazoic acid is explosive and poisonous in nature.
2)Preparation of ∝-amino acid-
Another use of Schmidt reaction is to synthesize ∝-amino acid from aceto acetic ester.